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Bruce Prins, Ph.D.

Professor of Biology
Biology Program Director

Office Phone: (951) 343-4266
E-mail: bprins@calbaptist.edu
Office Location: James Building, 461
Office Hours: M 11-2pm, T/Th 2-4pm, W 11-12, 2-3pm

Degree Major Emphasis Institution Year
Ph.D. Pharmacology and Toxicology University of California, Irvine 1992
B.A. Biology Point Loma College 1983

Courses Taught

General Biology
Principles of Biology
Human Anatomy and Physiology
Vertebrate Physiology
Comparative Anatomy
Pharmacology

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Academic Areas & Scholarly Interests

Pharmacology
Physiology
Biochemistry
Molecular biology of the cardiovascular system

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Teaching Experience

Cal State Long Beach: Biochemistry and Nutritional Biochemistry
Azusa Pacific University: Biochemistry and Pharmacology
Community Christian College: Biology and Chemistry
Arrowhead Christian Academy: Biology, Chemistry, Anatomy/Physiology, Biomed

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Research, Presentations, & Publications

Park H-W, Devera J, Prins BA, Bideshi DK 2011 The dual-activity insecticidal protein, Cry2Aa, does not enhance the mosquitocidal activity of Bacillus thuringiensis subsp. israelensis Journal of Asia-Pacific Entemology 14: 429-431

Domek MJ, Netzer P, Prins B, Nguyen T, Liang D, Wyle FA Warner A. 2001 Helicobacter pylori induces apoptosis in human epithelial gastric cells by stress activated protein kinase pathway. Helicobacter. Jun;6(2):110-5.

Weiler EW, Khalil-Manesh F, Gonick HC, Prins BA, Purdy RE, Sensharma DK. 1999 Na-K-ATPase inhibitor dissociated from hypertension-associated plasma protein. Am J Hypertens. 1999 Apr;12(4 Pt 1):364-73.

Morey, AK, Hu R-M, Pedram A, Prins BA, Levin ER 1998 Estrogen and progesterone inhibit the stimulated production of endothelin-1: Differential positive and negative regulatory mechanisms. Biochemical Journal 1998 March 15; 330 (Pt 3): 1097-1105.

Wang P, Feng J, Bahl J, Prins B, Levin ER 1998 IGF-1 induction of P53 and p21WAF1/CIP1 requires activation of MAP kinase in cardiac muscle cells. Biochem Biophys Res Commun. 1998 Apr 28;245(3):912-7.

Morey AK, Pedram A, Prins BA, Hu R-M, Biesiada E, Levin ER 1997 Estrogen and Progesterone inhibit vascular smooth muscle proliferation. Endocrinology. 1997 Aug;138(8):3330-9.

Prins BA, Biesiada E, Levin ER 1996 Natriuretic peptides and hypertension. Curr. Opinions. Nephrol. Hypertens. 5: 170-173. (Review Article)

Prins BA, Weber MJ, Hu R-M, Pedram A Daniels M, Levin ER 1996 Atrial natriuretic peptide inhibits mitogen-activated protein kinase through the clearance receptor: potential role in the inhibition of astrocyte proliferation. J. Biol. Chem. 271: 14156-14162.

Nazrio B, Hu R-M, Pedram A, Prins BA, Levin ER 1994 Atrial natriuretic peptide stimulates C-type natriuretic peptide production and secretion from endothelial cells. J. Clin. Invest. 94: 1151-1157.

Cahill L, Prins B, Weber M, McGaugh JL 1994 Memory for emotional events: involvement of B-adrengergic activation. Nature 371: 702-704.

Prins BA, Hu R-M, Nazario B, Pedram A, Frank HJL, Weber MA, Levin ER 1994 Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells. J. Biol. Chem. 269: 11938-11944

Hu R-M, Chuag M-Y, Prins B, Kashyap ML, Frank HJL, Pedram A, Levin ER 1994 High density lipoproteins stimulate the production and secretion of endothelin-1 from cultured bovine aortic endothelial cells. J. Clin Invest. 93: 1056-1062.

Weiler EWJ, Gonick HC, Prins BA, Purdy RE, Weber MA 1994 Characterization of a low molecular weight NA-K-ATPase inhibitor of urinary origin. Am. J. Med. Scie. 307: 27-35.

Khalil-Manseh F, Gonick HC, Weiler EW, Prins B, Weber MA, Purdy R, Ren Q 1994 Effect of chelation treatment with dimercaptosuccinic acid (DMSA) on lead-related blood pressure changes. Environ. Res. 65: 86-99.

Gonick HC, Weiler EW, Prins BA, Purdy RE 1993 Comparison of low-molecular weight plasma and urine NA-K-ATPase inhibitors/hypertensive factors. J. Cardiovasc. Pharm. 22: S69-S71.

Chalil-Manesh F, Gonick HC, Weiler EW, Prins B, Weber MA, Purdy RE 1993 Lead-induced hypertension: possible role of endothelial factors. Am. J. Hypertens. 6: 723-729.

Purdy RE, Prins BA, Weber MA, Bakhtiarian A, Smith JR, Kim MK, Nguyen T-H T, Weiler EWJ 1993 Possible novel action of ouabain: allosteric modulation of vascular serotonergic and angiotensinergic receptors. J. Pharm. Exp. Ther. 267: 228-237.

Prins BA, Weber MA, Purdy RE 1992 Norepinephrine amplifies the angiotensin-II-induced vasoconstriction in rabbit femoral artery. J. Pharm. Exp. Ther. 262: 198-203.

Purdy RE, Prins BA, Weber MA, Gonick HC, Weiler E 1991 Sodium-potassium adenosine triphosphatase inhibitory and vasoconstrictor activities in an extract derived from the urine f hypertensive patients. In: Actual Problems of Cardiac Failure, Tatishvili NI (ed) Georgian SSR Academy of Sciences, Georgia, USSR.

Weber MA, Purdy RE, Stupecky GL, Prins BA 1989 Mechanisms of angiotensin II potentiation of sympathomimetic arterial constriction. J. Vasc. Med. and Biol. 1: 7-12.

Weber MA, Weiler E, Gonick HC, Prins BA, Purdy RE 1989 Effect of a human derived sodium transport inhibitor on in vitro vascular reactivity. Am. J. Hypertens. 2: 754-761.

Prins BA, Weber MA, Purdy RE, Weiler E, Gonick HC 1988 Effect of a human urine derived sodium-potassium pump inhibitor on isolated rabbit femoral artery and atria. Proc. West. Pharm. Soc. 31: 301-303.

Purdy RE, Weber MA, Prins BA, Stupecky GL 1987 Angiotensin II-induced amplification of the vasoconstrictor response to norepinephrine and clonidine. Proc. West. Pharm. Soc. 30: 171-174.

Abstracts and Scientific Presentations:

Nazario, B, Hu R-M, Pedram A, Prins B, Levin ER 1994 Atrial natriuretic peptide stimulates C-type natriuretic peptide production and secretion from endothelial cells. 76th Annual Meeting of the Endocrine Society, Anaheim, CA 1528.

Hu R-M, Chuang M-Y, Prins B, Kashyap M, Frank HJL, Pedram A, Levin ER 1994 Human high density lipoprotein stimulates the production of endothelin-1 from cultured endothelial cells. 7th Annual meeting of the Endocrine Society, Anaheim, CA, 1526.

Prins BA, Weber MJ, Hu R-M, Pedram A, Daniels M, Levin ER 1994 Atrial natriuretic peptide inhibits mtogen-activated protein kinas (MAP-K) and astrocyte proliferation: Mediation through the clearance receptor. 76h Annual Meeting of the Endocrine Society, Anaheim, CA, 277.

Gonick HC, Weiler EWJ, Khalil-Manesh F, Prins BA, Purdy RE, Sensharma DK 1993 Hypertension-associated protein: carrier for natriuretic hormone? XII International Congress of Nephrology, Jerusalem, Israel (p. 526).

Prins BA, Hu R-M, Nazario B, Pedram A, Frank HJL, Weber MA, Levin ER 1993 Prostaglandins inhibit the production and secretion of endothelium from cultured endothelial cells. 75th Annual Meeting of the Endocrine Society, Las Vegas, NE.

Gonick HC, Weiler EWJ, Prins BA, Purdy RE 1992 Comparison of a low molecular weight plasma NA-K-ATPase inhibitor of urinary origin. Abstracts of the International Society of Hypertension.

Prins BA, Purdy RE, Komashoko AW, Weber MA 1992 Angiotensin I-induced vasoconstriction and contractile synergism with sympathomimetic agonists in rabbit femoral artery. FASEBJ. 6(4): A998.

Purdy RE, Prins BA, Kim MK, Nguyen T-HT, Weber MA 1992 Reversal of the in surmountable antagonism of EXP3892 by either losartan potassium or ouabain in rabbit femoral artery. FASEBJ. 6(4): A1011.

Prins BA, Purdy RE, Seng L, Jahangiri H. Weber MA 1992 Characterization of antiotensin II induced dilation in isolated rabbit ear artery. Proc. West. Pharm. Soc. 35: 250.

Prins BA, Jahangiri H, Weber MA, Purdy RE 1991 Angiotensin II-induced, endothelium independent relaxation of the rabbit ear artery: inhibition by DuP 753 and indomethacin. The Pharmacologist 33(3): 173.

Prins B, Purdy R, Weber M, Weiler E, Gonick H 1991 Human urine contains a substance that inhibits NA-K-ATPase and modulates the serotonin-induced vasoconstriction. Clin. Res. 39: 50A.

Weiler E, Gonick H, Prins B, Purdy R, Weber M 1991 Characgerization of a low molecular weight NA-K-ATPase inhibitor or urinary origin. Clin. Res. 39: 23A.

Weiler E, Gonick H, Prins B, Purdy R, Weber M 1990 Characterization of a low-molecular weight urinary inhibitor of NA-K-ATPase. Proc. XIth International Congress of Nephrology, Tokyo, Japan.

Khalil-Manesh F, Gonick H, Weiler E, Prins B, Purdy R 1990 Lead-induced hypertension. Proc. XIth International Congress of Nephrology, Tokyo, Japan.

Prins BA, Purdy RE, Weber MA, Movahedi H, Shariati S 1989 The degree of atrial natriuretic peptide-induced contraction inhibition is dependent on spare receptors. Proc. West. Pharm. Soc. 32: 263.

Khalil-Manesh F, Weiler E, Gonick H, Weber M, Prins B 1989 Lead-related hypertension: Effect on faxular reactivity (in vivo). The Toxicologist 9: 279.

Prins BA, Weber MA, Purdy RE 1989 Norepinephrine amplifies the angiotensin-II induced contractile response of the rabbit femoral artery. The Pharmacologist 31: 143.

Khalil-Manesh F, Weiler E, Gonick HC, Weber M, Prins B 1988 Effect of lead on vascular reactivity in vivo and NA-K-ATPase in vitro: relevance to hypertension? Am. J. Hypertens. 1: (3pt.2); 64A.

Weber MA, Gonick HC, Weiler E, Prins BA, Purdy RE 1988 Vascular effects of a sodium transport inhibitor. Am. J. Hypertens. 1: (3pts.2); 47A.

Prins BA, Purdy RE, Weber MA, Weiler E, Gonick HC 1988 The effects of a human humoral sodium pump inhibitor on isolated rabbit cardiovascular preparations. FASEB J. 2: A603.

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Church Membership & Activities

The River Christian Reformed Church

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Community Service & Involvement

Leader, International Service Project, CBU 2013
Board Chair, Community Christian College, 2011-2013
President, Church Council, 2008-2010

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Interests & Hobbies

Wife: Debra
Sons: Mitchell (21),Cameron (19)
Daughter: Clara (13)

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Personal Philosophy

2 Chronicles 20:12 We do not know what to do, but our eyes are on You.

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